Tumor necrosis factor (TNF)-α induces leptin production through the p55 TNF receptor
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Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor.
Tumor necrosis factor (TNF)-alpha acts directly on adipocytes to increase production of the lipostatic factor, leptin. However, which TNF receptor (TNFR) mediates this response is not known. To answer this question, leptin was measured in plasma of wild-type (WT), p55, and p75 TNFR knockout (KO) mice injected intraperitoneally with murine TNF-alpha and in supernatants from cultured WT, p55, and...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2000
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.2000.278.2.r537